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ArterioRestore: What's Inside
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Cardiologist-formulated Daily Artery Support

ArterioRestore

Cardiologist-formulated with 4 potent ingredients that work together to support your overall cardiovascular health, healthy blood flow and circulation, and healthy artery function as you age.†

  • Supports healthy circulation and blood flow to all critical areas.†
  • Helps maintain healthy cholesterol already in normal range.†
  • Supports healthy artery function and overall cardiovascular wellness.†

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Quality and Safety Matter

Cardiologist-formulated
Third-Party Tested
Current Good Manufacturing Practices
Made in the U.S. from Globally Sourced Ingredients
Gluten Free

ArterioRestore at a Glance

Purchase Confidence

90-Day Money-Back Guarantee

Take a full 90 days to try ArterioRestore. That allows time for the compounds to build up in your system. If you’re not thrilled for any reason, email support@nuvestra.com or call 888-528-7532 for a refund.

Shipping & Returns

Most U.S. orders ship in 1 business day and typically arrive 3–5 business days after shipment. Contact us within 90 days after arrival if ArterioRestore is not right for you.

Why It’s Safe
  • Cardiologist-formulated
  • Third-party tested
  • Produced under current good manufacturing practices
  • Made in the U.S. from globally sourced ingredients
  • Gluten free

Check with your doctor before taking ArterioRestore if you use any medications, especially blood thinners or antiplatelet medication, or if you have a procedure scheduled.

Formula & Use

What’s in It
Unaltered ArterioRestore Supplement Facts panel
  • Nattokinase – Supports the body’s normal fibrin-clearing process.
  • Bergamot – Supports healthy cholesterol already in normal range.
  • Rutin – Provides antioxidant support to help protect the artery lining for healthy artery function.
  • Gotu Kola – Supports normal collagen formation to help maintain healthy artery walls and circulation.†
How to Take It

Take two capsules daily with water, preferably with breakfast or your first meal.

Why It Works

Each ingredient works synergistically with the others to support healthy artery function in one simple formula, cardiologist-designed, for peace of mind, so you can sleep well at night.

  • Supports Fibrin Cleanup – Nattokinase provides concentrated enzyme activity to support your body’s normal fibrin-clearing process, healthy blood flow, and healthy circulation.†
  • Supports Healthy Cholesterol – Bergamot provides concentrated citrus bioflavonoids to support your body’s normal cholesterol processing and help maintain healthy cholesterol already in normal range.†
  • Supports Healthy Arteries – Rutin’s antioxidant activity helps protect the delicate artery lining from free radical damage associated with aging, while gotu kola’s triterpenes support normal collagen formation for healthy artery walls.†

Your Experience

What to Expect*
  • 1 Week – Start taking 2 capsules each morning with breakfast (or your first meal) to allow the artery-supporting compounds to start building up.
  • 1 Month – As artery-supporting compounds build up, you may start noticing changes - steadier energy, feeling less drained, daily activities getting easier.
  • 3 Months – Now that your body has the support it needs for healthy circulation and blood flow, walks, errands, and family time may be easier.
  • 6 Months – Normal everyday confidence may return as steady energy, clearer thinking and better sleep become much more consistent.
  • 12 Months – Peace of mind may return now that you live life on your own terms, enjoying what you want, when you want, so you don’t miss out on the joys of life.

*Results and timing may vary by individual

Why It’s Better
  • Full-strength nattokinase at 6,000 FU per serving
  • All four key healthy artery-supporting ingredients
  • Cardiologist formulated
  • Third-party tested for potency and purity
What You’ll Enjoy*
  • Steadier Energy – Knock out everything on your checklist throughout the day, with plenty of energy left in the tank to do whatever it is you love to do the most.
  • Fun with Family and Friends – Enjoy your favorite activities again, spending time with your family and friends, ensuring you don't miss out on the most important things in life.
  • Peace of Mind – Sleeping well at night, knowing you made the smart choice to provide your arteries the nourishing support they need for a healthy, long life.

*Results and timing may vary by individual

Saves You Money

Not only is ArterioRestore designed to be more effective, it's also designed to save you a bundle.

ArterioRestoreOursBought SeparatelyOthers
Nattokinase6,000 FU per Serving✓$29.99
Bergamot Extract375 mg per Serving✓$29.66
Rutin300 mg per Serving✓$6.82
Gotu Kola180 mg per Serving✓$12.50
30-Day Supplyper bottle$49*$79

You Save $30 a Month*($360 a Year)

*With the 6-bottle subscription. Compared with single-ingredient products using the same branded ingredients, based on retail prices observed August 2026.

Questions I Get Most

How quickly does it start working?

What Happens Inside Your Arteries Matters

Flexible Arteries Support Healthy Blood Flow

Red Blood CellsCholesterol

Healthy circulation helps carry oxygen and nutrients throughout your body. Healthy arteries relax and widen when needed to help keep that blood moving. But as we get older and everyday stress takes its toll, arteries may become less responsive. They're less flexible.

And when arteries do not relax and widen as readily due to a loss in flexibility, blood flow may be affected. That means oxygen and nutrients may not reach your heart, brain, and other critical areas as efficiently, and that's when more serious problems may emerge.

Artery Flexibility Declines With Age

Source: Zócalo & Bia, 2021 · Table S12

*FMD measures how much an artery widens when blood flow increases.

The Problem Starts With “Sticky Arteries”

That ability to relax and widen depends in part on the health of your artery lining. When functioning well, this delicate lining provides a smooth inner surface for blood to flow through. It also helps signal the artery walls to relax when more blood flow is needed.

Unfortunately, as we get older, our arteries become sticky, allowing cholesterol and other particles circulating in the bloodstream to get trapped and accumulate. Arteries start to lose their flexibility… and that’s when things can start to go downhill.

How Arteries Get Sticky

  1. Artery Lining Wears Down

    Aging and everyday wear and tear can take a toll on the delicate protective lining of your arteries. Fortunately, your body has a natural way to fix this wear and tear, which starts with fibrin.

    Red Blood CellsCholesterolFibrin

  2. Fibrin Helps Seal the Area

    Fibrin forms a temporary "sticky" mesh that helps stabilize the damaged area and draw in the immune cells involved in repair. Once its job is done, fibrin is naturally cleared away.

    Red Blood CellsCholesterolFibrin

  3. Excess Fibrin Gets Sticky

    Unfortunately, your ability to clear excess fibrin declines with age. Excess fibrin builds up into a sticky web that can trap cholesterol and other particles. And that's when larger problems may arise.

    Red Blood CellsCholesterolFibrin

Your Body’s Ability to Dissolve Sticky Fibrin Drops With Age

Source: Smith et al., Journal of Physiology, 2003

*Measures tPA release. tPA is a natural enzyme that triggers the body’s fibrin-clearing process.

That’s Why We Created ArterioRestore

ArterioRestore was created to make daily artery support simpler: one formula that supports the body’s normal fibrin-clearing process, healthy blood flow and artery function.†

Each ingredient works synergistically with the others to support healthy artery function in one simple formula, cardiologist-designed, for peace of mind, so you can sleep well at night.

ArterioRestore bottle
Dr. George Yiachos
Cardiologist-formulatedDr. George Yiachos, MD
  • Harvard-Trained Preventive Cardiologist
  • Board-certified in cardiology
  • 30 Years at NYU Langone, the #1 Ranked Academic Medical Center in the U.S.

Supports Fibrin Cleanup

Nattokinase provides concentrated enzyme activity to support your body’s normal fibrin-clearing process, healthy blood flow, and healthy circulation.†

Supports Healthy Cholesterol

Bergamot provides concentrated citrus bioflavonoids to support your body’s normal cholesterol processing and help maintain healthy cholesterol already in normal range.†

Supports Healthy Arteries

Rutin’s antioxidant activity helps protect the delicate artery lining from free radical damage associated with aging, while gotu kola’s triterpenes support normal collagen formation for healthy artery walls.†

What’s In It

We scoured the research studies to pinpoint the most powerful ingredients for healthy artery support. And then we went on a worldwide hunt for the best sources of each.

After multiple rounds of meticulous testing, we settled on the best sources that met our exceptional standards for potency, purity, and effectiveness.

Natto soybeans

Nattokinase

Supports the body’s normal fibrin-clearing process.†

  • Fibrin-Clearing Enzyme - Found in natto, Japan’s traditional fermented soybean food.†
  • 20,000 FU Per Gram - Concentrated enzyme activity to support your body’s normal fibrin-clearing process.† We tested NattoSEB® using multiple methods to confirm fibrin breakdown matched or exceeded our research benchmark.
  • 6,000 FU Per Serving - Your two daily capsules deliver 300 mg of NattoSEB®. That’s the full daily enzyme-activity amount tested in a 26-week clinical study.33 Three times the enzyme activity of a normal 2,000 FU serving.
Bergamot fruit

Bergamot

Supports healthy cholesterol already in normal range.†

  • Calabrian Bergamot Juice - Extracted from citrus grown along southern Italy’s Mediterranean coast.
  • 39% Concentrated Flavonoids - Concentrated citrus compounds that support your body’s normal cholesterol processing. This helps maintain healthy cholesterol already in normal range.†
  • 375 mg Per Serving - Your two daily capsules deliver the full daily amount of Bergavit® tested in a four-month clinical study.65
Sophora flower buds

Rutin

Provides antioxidant support to help protect the artery lining for healthy artery function.†

  • Pagoda Tree Flower Buds - A naturally rich source of rutin from the unopened blossoms of Sophora japonica, a tree cultivated across East Asia.
  • More Than 95% Rutin - A highly concentrated plant antioxidant that helps protect the delicate artery lining from free radical damage associated with aging to support healthy blood flow.†66
  • 300 mg Per Serving - Powerful antioxidant support in your two daily capsules, with more than 285 mg of rutin itself.†
Gotu kola leaves

Gotu Kola

Supports normal collagen formation to help maintain healthy artery walls and circulation.†

  • Whole-Herb Extract - Naturally rich in plant compounds called triterpenes, Centella asiatica, commonly known as gotu kola, flourishes in the warm, nutrient-rich regions of tropical Asia.
  • Concentrated Triterpenes - Support normal collagen formation to help maintain the proper structure of artery walls for healthy circulation.†67
  • 180 mg Per Serving - A concentrated whole-herb extract containing all four key triterpenes in your two daily capsules.
Unaltered ArterioRestore Supplement Facts panel

What to Expect*

Daily consistency is key. Each day you nourish your arteries with ArterioRestore is another day its artery-supporting compounds build up for maximum effect.

1 Week

Start taking 2 capsules each morning with breakfast (or your first meal) to allow the artery-supporting compounds to start building up.

1 Month

As artery-supporting compounds build up, you may start noticing changes - steadier energy, feeling less drained, daily activities getting easier.

3 Months

Now that your body has the support it needs for healthy circulation and blood flow, walks, errands, and family time may be easier.

6 Months

Normal everyday confidence may return as steady energy, clearer thinking and better sleep become much more consistent.

12 Months

Peace of mind may return now that you live life on your own terms, enjoying what you want, when you want, so you don’t miss out on the joys of life.

*Results and timing may vary by individual

Why It’s Better

Cardiologist-formulated with 4 potent ingredients that work together to support your overall cardiovascular health, healthy blood flow and circulation, and healthy artery function as you age.†

ArterioRestoreOursTypicalOther
Full-strength nattokinaseat 6,000 FU per serving×
All Four Key HealthyArtery-Supporting IngredientsNattokinase · Bergamot · Rutin · Gotu Kola×
Cardiologist FormulatedShaped by treating thousands of patients×
Third-Party Tested for Potency and PurityMeticulously tested for the quality you deserve×
90-Day Money-Back GuaranteeTry it for 90 days – love it or your money back×

How to Take It

The same older man calmly pouring a fresh glass of water with ArterioRestore integrated naturally on the breakfast table
1

Pour a Glass of Water

The same man looking warmly at exactly two small capsules pinched against a clear background
2

Take Out Two Small Capsules

The same older man calmly drinking water with ArterioRestore integrated naturally on the breakfast table
3

Take With Breakfast (or First Meal)

A Note From Dr. Yiachos

Dr. George Yiachos in his office
Dr. George Yiachos, MD
  • Harvard-Trained Preventive Cardiologist
  • Board-certified in cardiology
  • 30 Years at NYU Langone, the #1 Ranked Academic Medical Center in the U.S.
Dear Friend,

After more than three decades in cardiology, I couldn't be more excited to introduce ArterioRestore to the world. I'm extremely proud of the unique combination of synergistic ingredients that were hand-selected to support healthy blood flow and circulation, proper artery function, and overall cardiovascular wellness.

I've personally tested dozens of supplements over the years on myself. As well as recommended many to my patients. And if there's one thing I've learned that makes the difference, it's quality. That's why I demanded that every ingredient we used be extensively tested for purity, potency and contaminants.

When you try ArterioRestore, I advise you take it consistently to give enough time for the active compounds to take effect. As with everything helpful in life, consistency is key. That gives you the best shot to gradually start enjoying life again with the energy your days demand and the peaceful sleep at night you deserve.

To your health and happiness,Dr. George Yiachos, MD
90-day 100 percent money-back guarantee

Your Purchase Is Protected by Our 90-Day Risk-Free 100% Guarantee

Take a full 90 days to feel the difference – more energy, healthy circulation, and real peace of mind about your heart health. If you’re not thrilled for any reason, contact us anytime within those 90 days for a complete refund. Empty bottle, no problem. Just call us at 888-528-7532 and we’ll issue you a prompt, courteous refund.

What You’ll Enjoy*

An older couple smiling naturally while preparing a meal together

Steadier Energy

Knock out everything on your checklist throughout the day, with plenty of energy left in the tank to do whatever it is you love to do the most.

A smiling grandmother gardening with her grandchild

Fun with Family and Friends

Enjoy your favorite activities again, spending time with your family and friends, ensuring you don't miss out on the most important things in life.

ArterioRestore beside water and a weekly pill organizer

Peace of Mind

Sleeping well at night, knowing you made the smart choice to provide your arteries the nourishing support they need for a healthy, long life.

*Results and timing may vary by individual

3 Steps to Get Started

1Place Your Order Today
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Max Savings
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Most Popular
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  • Ships within 1 business day
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  • Ships every month
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  • Ships within 1 business day

$294.00 today · ships every 6 months at $294.00. Free shipping.

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Frequently Asked Questions

Take two capsules daily with water, preferably with breakfast or your first meal.

Scientific References

The full reference list is provided below. Numbered links in this page point to the corresponding source. Research on individual ingredients is not a clinical trial of the finished ArterioRestore formula.

  1. Zhengping Hu, Issahy Cano, Patricia A. D’Amore. Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation. Frontiers in Cell and Developmental Biology. 2021.
  2. Li Li, Joseph V. Bonventre. Endothelial Glycocalyx: Not Just a Sugar Coat. American Journal of Respiratory and Critical Care Medicine. 2016.
  3. Ignatios Ikonomidis, George Pavlidis, Vaia Lambadiari, et al. Endothelial glycocalyx and microvascular perfusion are associated with carotid intima-media thickness and impaired myocardial deformation in psoriatic disease. Journal of Human Hypertension. 2022.
  4. Dae Hyun Lee, Martijn J. C. Dane, Bernard M. van den Berg, et al. Deeper Penetration of Erythrocytes into the Endothelial Glycocalyx Is Associated with Impaired Microvascular Perfusion. PLoS ONE. 2014.
  5. Vaia Lambadiari, George Pavlidis, Foteini Kousathana, et al. Effects of Different Antidiabetic Medications on Endothelial Glycocalyx, Myocardial Function, and Vascular Function in Type 2 Diabetic Patients: One Year Follow–Up Study. Journal of Clinical Medicine. 2019.
  6. Ignatios Ikonomidis, John Thymis, Panagiotis Simitsis, et al. Impaired Endothelial Glycocalyx Predicts Adverse Outcome in Subjects Without Overt Cardiovascular Disease: a 6-Year Follow-up Study. Journal of Cardiovascular Translational Research. 2022.
  7. NYU Langone Health. Cardiology. NYU Langone Health. n.d.
  8. Niels Graudal, Gesche Jürgens, Bo Baslund, et al. Compared With Usual Sodium Intake, Low- and Excessive-Sodium Diets Are Associated With Increased Mortality: A Meta-Analysis. American Journal of Hypertension. 2014.
  9. Patty W Siri-Tarino, Qi Sun, Frank B Hu, et al. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. The American Journal of Clinical Nutrition. 2010.
  10. Archana Ramireddy, Sumeet S. Chugh. Do peak times exist for sudden cardiac arrest?. Trends in Cardiovascular Medicine. 2021.
  11. UCLA Health. Most heart attack patients’ cholesterol levels did not indicate cardiac risk. UCLA Health. 2009.
  12. Uffe Ravnskov, David M Diamond, Rokura Hama, et al. Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open. 2016.
  13. Duke Health. Statin Guidelines Miss Middle-Age Patients and Over-Target Seniors. Duke Health. 2015.
  14. Jerome P. Kassirer. Why Should We Swallow What These Studies Say?. The Washington Post. 2004.
  15. Arthur Phillips. Is the American Heart Association for Sale? AHA leadership’s financial ties to the pharmaceutical & food industries. UNITE HERE. n.d.
  16. David Newman. Statins for Heart Disease Prevention (Without Prior Heart Disease). TheNNT. 2015.
  17. Guiomar Mendieta, Stuart Pocock, Virginia Mass, et al. Determinants of Progression and Regression of Subclinical Atherosclerosis Over 6 Years. Journal of the American College of Cardiology. 2023.
  18. G. de la Serna. Fibrinogen: a new major risk factor for cardiovascular disease. A review of the literature.. The Journal of Family Practice. 1994.
  19. Centers for Disease Control and Prevention. Heart Disease Facts. Centers for Disease Control and Prevention. 2024.
  20. American Heart Association. 2025 Heart Disease and Stroke Statistics Update Fact Sheet: At-a-Glance. American Heart Association. 2025.
  21. American Heart Association. Clotting Protein May Be Link To Heart Disease. ScienceDaily. 2000.
  22. Yoshiki Aoshima, Hiroyuki Sakakibara, Taka-aki Suzuki, et al. Nocturnal Light Exposure Alters Hepatic Pai-1 Expression by Stimulating the Adrenal Pathway in C3H Mice. Experimental Animals. 2014.
  23. Katri Räikkönen, Riitta Lassila, Liisa Keltikangas-Järvinen, et al. Association of Chronic Stress With Plasminogen Activator Inhibitor–1 in Healthy Middle-aged Men. Arteriosclerosis, Thrombosis, and Vascular Biology. 1996.
  24. Antti-Pekka Elomaa, Heli Koivumaa-Honkanen, Leo Niskanen, et al. Self-reported sleep disturbance is associated with elevated levels of PAI-1 in individuals with a recorded history of depressive symptoms. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2013.
  25. Hiroshi Harada, Yoshiaki Kanai, Mikiyuki Katagiri, et al. Fatty acid profiles among individuals in Nagano, Japan: potential effects on health. Progress in Nutrition. 2019.
  26. Nobuyuki Miyai, Kiyoshi Uchiba, Hirofumi Tomiyama, et al. District Differences in the Measured Values of Arterial Stiffness in Japan. Circulation Reports. 2021.
  27. Kirk Spitzer. Secrets From the Longest-Living Place on Earth. AARP Bulletin. 2014.
  28. Yanchun Liu, Yanxia Han, Lingli Cao, et al. Analysis of Main Components and Prospects of Natto. Advances in Enzyme Research. 2021.
  29. Chiiki no Iremono (Region Case). Natto consumption ranking by prefecture (2019) [English translation of Japanese title]. 2020.
  30. Chisato Nagata, Keiko Wada, Takashi Tamura, et al. Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study. The American Journal of Clinical Nutrition. 2017.
  31. Hongjie Chen, Eileen M McGowan, Nina Ren, et al. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights. 2018.
  32. Hongjie Chen, Jiepeng Chen, Fuping Zhang, et al. Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. Frontiers in Cardiovascular Medicine. 2022.
  33. N. N. Ren, H. J. Chen, Y. Li, et al. [A clinical study on the effect of nattokinase on carotid artery atherosclerosis and hyperlipidaemia]. Zhonghua Yi Xue Za Zhi. 2017.
  34. Chiharu Fujita, Yukio Usui, Masanori Inoue. Effects of Bacillus subtilis Var. Natto Products on Capillary Blood Flow in Healthy Subjects with Peripheral Coldness: A Double-Blind, Placebo-Controlled, Randomized Parallel Study. Food and Nutrition Sciences. 2022.
  35. Ji Young KIM, Si Nae GUM, Jean Kyung PAIK, et al. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial. Hypertension Research. 2008.
  36. Giuseppe Mazzola, Mariangela Rondanelli, Giovanna Baron, et al. Bergamot (Citrus bergamia), a (Poly)Phenol-Rich Source for Improving Osteosarcopenic Obesity: A Systematic Review. Foods. 2024.
  37. Micaela Gliozzi, Ross Walker, Saverio Muscoli, et al. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. International Journal of Cardiology. 2013.
  38. Chih-Wei Hsia, Ming-Ping Wu, Ming-Yi Shen, et al. Regulation of Human Platelet Activation and Prevention of Arterial Thrombosis in Mice by Auraptene through Inhibition of NF-κB Pathway. International Journal of Molecular Sciences. 2020.
  39. Peter P. Toth, Angelo M. Patti, Dragana Nikolic, et al. Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study. Frontiers in Pharmacology. 2016.
  40. Bonnie Prescott. Flavonoid compound can prevent blood clots. Harvard Gazette. 2012.
  41. Hadi Bazyar, Ahmad Zare Javid, Akram Ahangarpour, et al. The effects of rutin supplement on blood pressure markers, some serum antioxidant enzymes, and quality of life in patients with type 2 diabetes mellitus compared with placebo. Frontiers in Nutrition. 2023.
  42. Yushi Hashizume, Mahamadou Tandia. Monoglucosyl rutin, a flavonoid glycoside, improves low-density lipoprotein-cholesterol levels in healthy adults: A randomized controlled trial. Functional Foods in Health and Disease. 2024.
  43. Reema Jasuja, Freda H. Passam, Daniel R. Kennedy, et al. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. Journal of Clinical Investigation. 2012.
  44. Azizah Ugusman, Zaiton Zakaria, Kien Hui Chua, et al. Role of Rutin on Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells. The Scientific World Journal. 2014.
  45. L. Incandela, G. Belcaro, A. N. Nicolaides, et al. Modification of the Echogenicity of Femoral Plaques after Treatment with Total Triterpenic Fraction of Centella aslatica: A Prospective, Randomized, Placebo-Controlled Trial. Angiology. 2001.
  46. M. R. Cesarone, G. Belcaro, A. N. Nicolaides, et al. Increase in Echogenicity of Echolucent Carotid Plaques after Treatment with Total Triterpenic Fraction of Centella asiatica: A Prospective, Placebo-Controlled, Randomized Trial. Angiology. 2001.
  47. Gianni Belcaro, Mark Dugall, Edmondo Ippolito, et al. Pycnogenol® and Centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events. Minerva Cardiology and Angiology. 2016.
  48. Fifit Eka Furi Astutik, Diah Fauzia Zuhroh, Moh. Rizqi Lazuardi Ramadhan. The effect of gotu kola (Centella asiatica L.) tea on blood pressure of hypertension. Enfermería Clínica. 2021.
  49. Nyuk Jet Chong, Zoriah Aziz. A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency. Evidence-Based Complementary and Alternative Medicine. 2013.
  50. Yong Joon Jeong, Hyelin Jeon, Se Chan Kang. A Randomized, Double-Blind, Placebo-Controlled Parallel Study on the Efficacy and Safety of Centella asiatica L. Extract for Reducing Alanine Transaminase (ALT) Level in Subjects with Elevated ALT. Applied Sciences. 2021.
  51. Lugkana Mato, Jintanaporn Wattanathorn, Supaporn Muchimapura, et al. Centella asiatica Improves Physical Performance and Health‐Related Quality of Life in Healthy Elderly Volunteer. Evidence-Based Complementary and Alternative Medicine. 2011.
  52. Jintanaporn Wattanathorn, Lugkana Mator, Supaporn Muchimapura, et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. Journal of Ethnopharmacology. 2008.
  53. Leslee J. Shaw, C. Noel Bairey Merz, Carl J. Pepine, et al. The Economic Burden of Angina in Women With Suspected Ischemic Heart Disease. Circulation. 2006.
  54. Seth S. Martin, Aaron W. Aday, Norrina B. Allen, et al. 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association. Circulation. 2025.
  55. Francesco Menichini, Rosa Tundis, Monica R. Loizzo, et al. Citrus medica L. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016.
  56. American Heart Association News. Heart failure projected to increase dramatically, according to new statistics. American Heart Association. 2017.
  57. The GBD 2016 Lifetime Risk of Stroke Collaborators. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016. New England Journal of Medicine. 2018.
  58. Carlos Henrique Miranda, Marcos de Carvalho Borges, André Schmidt, et al. Evaluation of the endothelial glycocalyx damage in patients with acute coronary syndrome. Atherosclerosis. 2016.
  59. Francesco De Rango, Alberto Montesanto, Maurizio Berardelli, et al. To Grow Old in Southern Italy: A Comprehensive Description of the Old and Oldest Old in Calabria. Gerontology. 2011.
  60. P. Gareri, R. Lacava, M.G. Rossi, et al. Hypertension in a group of centenarians. Archives of Gerontology and Geriatrics. 1996.
  61. William E. Schutzer, Scott L. Mader. Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly. International Journal of Hypertension. 2012.
  62. Shampa Chatterjee. Endothelial Mechanotransduction, Redox Signaling and the Regulation of Vascular Inflammatory Pathways. Frontiers in Physiology. 2018.
  63. Daniel R. Machin, Samuel I. Bloom, Robert A. Campbell, et al. Advanced age results in a diminished endothelial glycocalyx. American Journal of Physiology-Heart and Circulatory Physiology. 2018.
  64. OECD. Health at a Glance 2023. Health at a Glance. 2023.
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Supplement Facts

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Supplement Facts. Serving size: 2 capsules. Servings per container: 30. Amount per serving: Bergamot Orange Extract (Citrus bergamia) (fruit), standardized to 39% total flavonoids (as Bergavit® 40), 375 mg; Nattokinase 20,000 FU/g (as NattoSEB®), 300 mg; Rutin (Sophora japonica L.) (flower buds), greater than 95% quercetin-3-O-rutinoside, 300 mg; Gotu Kola (Centella asiatica) (whole herb), standardized to 40% Asiaticosides, 180 mg. Daily Value not established.